The human body is exposed to a wide variety of toxins on a daily basis, including chemicals found in foods and drinks, environmental toxins and pharmaceuticals drugs. The liver is the body’s main detoxification organ and provides enzyme systems that safely process and remove xenobiotics and unhealthy hormone metabolites out of the body. These detoxification systems are very complex and require a variety of nutrients for optimal function. There are two main pathways of detoxification in the liver, known as Phase I and Phase II. Phase I, composed mainly of cytochrome P450 enzymes, involves non-reactive compounds undergo specific reactions which use oxygen to form a reactive site on the compound. Most pharmaceuticals are metabolized through Phase I biotransformation. This prepares the metabolite for the next step of detoxification, known as Phase II. Phase II is a crucial step- if molecules from Phase I are not fully metabolized by Phase II conjugation, they may cause free radical damage to proteins, RNA and DNA within the cell. Phase II reactions result in the biotransformation of fat-soluble compounds into water-soluble compounds that can then be excreted in the urine, bile or stool. DrJsNatural Simple Detox botanicals and plant extracts contain phytonutrients, antioxidants and other compounds that naturally protect plants from environmental challenges including exposure to radiation, toxins and infectious agents. In humans, these biologically active compounds have been shown to increase cellular defenses, up-regulate liver detoxification pathways and protect DNA.
Silymarin (Milk Thistle Seed Extract) or Milk thistle (Silybum marianum) is an annual plant indigenous to Europe and the United States and has been used for centuries as a botanical medicine to support liver health. Silybum marianum contains silymarin, the biologically active component found in the seeds and leaves of this plant. Silymarin provides liver protective effects via several mechanisms of action including inhibiting lipid peroxidation, supporting liver detoxification through enhancement of the liver’s glucuronidation pathways, and protection against glutathione depletion. Silymarin has been shown to increase hepatocyte protein synthesis resulting in enhanced detoxification function.
Dandelion Root Extract– Dandelion (Taraxacum officinale) is a native plant to the United States and Europe, where the leaves and roots have been used as food and herbal medicine. The German Commission E and European Scientific Cooperative for Phytotherapy have approved the use of dandelion root to support hepatic and biliary function. Studies conducted in animals, have shown that dandelion root increases bile secretion as well as glutathione peroxidase, glutathione reductase and SOD (superoxide dismutase).
Artichoke Root– studies have shown that artichoke, categorized as a choleretic, stimulates the body’s natural production of bile, which is responsible for emulsifying fats in our diets. Artichoke also increases the surface area of fats, which allows enzymes to more efficiently break them down. Artichoke provides an excellent vegetarian alternative to detox bile, which is traditionally used in digestive supplements to support bile production. Artichoke Leaf Extract is one of the oldest cultivated plants. The ancient Greeks and Romans considered artichoke to be a valuable digestive aid. In traditional European medicine, the leaves of the artichoke were used as a diuretic to stimulate the kidneys and as a choleretic to stimulate the flow of bile from the liver and gallbladder. Artichoke leaf extracts have been shown to provide antioxidant and liver support, including the maintenance of healthy cholesterol levels and the prevention of lipid oxidation.
Senna Leaf extract- the leaves and the fruit of the plant are used to make medicine. Senna is an FDA-approved nonprescription laxative. It is used to treat constipation and also to clear the bowel before diagnostic tests such as colonoscopy. Senna is also used for irritable bowel syndrome (IBS), hemorrhoids, and weight loss.
Casanthranol USP (Cascara Sagrada bark extract)- Casanthranol is a stimulant type of laxative. The ingredient irritates the lining of the bowel to secrete fluid and so produce softer or more liquid bowel movements. Docusate or casanthranol is basically a detergent that is not absorbed by the body. It encourages the mixture of water and dietary fat within the stool, making the stool softer. It does not hold water like some bulking agents nor does it stimulate the bowel like true laxatives.
Sarsaparilla is a plant. The root is used to make medicine. Sarsaparilla is used for treating psoriasis and other skin diseases, rheumatoid arthritis(RA), and kidney disease; for increasing urination to reduce fluid retention; and for increasing sweating.
Mexican and Honduran sarsaparillas are used for treating gonorrhea, fevers, and digestive disorders. In manufacturing, sarsaparilla is used as a flavoring agent in foods, beverages, and pharmaceuticals. Chemicals in sarsaparilla might help decrease joint pain and itching, and might also reduce bacteria. Other chemicals might combat pain and swelling (inflammation), and also protect the liver against toxins.