The human body is exposed to a wide variety of toxins on a daily basis, including chemicals found in foods and drinks, environmental toxins and pharmaceuticals drugs. The liver is the body’s main detoxification organ and provides enzyme systems that safely process and remove xenobiotics and unhealthy hormone metabolites out of the body. These detoxification systems are very complex and require a variety of nutrients for optimal function. There are two main pathways of detoxification in the liver, known as Phase I and Phase II. Phase I, composed mainly of cytochrome P450 enzymes, involves non-reactive compounds undergo specific reactions which use oxygen to form a reactive site on the compound. Most pharmaceuticals are metabolized through Phase I biotransformation. This prepares the metabolite for the next step of detoxification, known as Phase II. Phase II is a crucial step- if molecules from Phase I are not fully metabolized by Phase II conjugation, they may cause free radical damage to proteins, RNA and DNA within the cell. Phase II reactions result in the biotransformation of fat-soluble compounds into water-soluble compounds that can then be excreted in the urine, bile or stool. DrJsNatural Simple Cleanse botanicals and plant extracts contain phytonutrients, antioxidants and other compounds that naturally protect plants from environmental challenges including exposure to radiation, toxins and infectious agents. In humans, these biologically active compounds have been shown to increase cellular defenses, up-regulate liver detoxification pathways and protect DNA.
Fennel seed– fennel is a perennial herb belonging to the parsley (Umbelliferae) family; a large family of herbs and spices which also includes some of other common members such as caraway, dill, anise, cumin…etc. Scientific name of fennel is Foeniculum vulgare var, Dulce. It is a perennial, pleasant-smelling herb with yellow flowers. It is native to the Mediterranean, but is now found throughout the world. Fennel is an excellent source of vitamin C. It is also a very good of dietary fiber, potassium, molybdenum, manganese, copper, phosphorus and folate. In addition,fennel is a good source of calcium, pantothenic acid, magnesium, iron and niacin. Fennel seeds indeed contain numerous flavonoid anti-oxidants like kaempferol and quercetin. These compounds function as powerful antioxidants by removing harmful free radicals from the body thus offer protection from cancers, infection, aging and degenerative neurological diseases. Fennel seeds also are a rich source of dietary fiber for example, 100 g seeds provide 39.8 g of fiber. Much of this roughage is metabolically inert insoluble fiber, which helps increase the bulk of the food by absorbing water throughout the digestive system and easing constipation problems.
Further, dietary fibers bind to bile salts (produced from cholesterol) and decrease their re-absorption in the colon. It thus helps lower serum LDL cholesterol levels. Together with flavonoid anti-oxidants, fiber composition of fennel helps protect the colon mucosa from cancers. Fennel seeds concentrated source of minerals like copper, iron, calcium, potassium, manganese, selenium, zinc, and magnesium. Copper is essential for the production of red blood cells. Iron is required for red blood cell formation. Zinc is a co-factor in many enzymes that regulate growth and development, sperm generation, digestion and nucleic acid synthesis. Potassium is an important component of cell and body fluids that helps controlling heart rate and blood pressure. The human body uses manganese as a cofactor for the important antioxidant enzyme, superoxide dismutase.
Furthermore, fennel seeds indeed are the storehouse for many vital vitamins. Vitamin-A, vitamin-E, vitamin-C as well as many B-complex vitamins like thiamin, pyridoxine, riboflavin and niacin particularly are concentrated in these seeds.
Aloe vera (Aloe barbadensis) or lily of the desert- Aloe vera’s use can be traced back 6,000 years to early Egypt, where the plant was depicted on stone carvings. Known as the “plant of immortality,” aloe was presented as a funeral gift to pharaohs. Historically, aloe vera has been used for a variety of purposes, including treatment of wounds, hair loss, and hemorrhoids; it has also been used as a laxative. Two substances from aloe vera, the clear gel and the yellow latex, are used in health products today. Aloe gel is primarily used topically (applied to the skin) as a remedy for skin conditions such as burns, frostbite, psoriasis, and cold sores, but it may also be taken orally (by mouth) for conditions including osteoarthritis, bowel diseases, and fever. Aloe latex is taken orally, usually for constipation. Aloe latex contains strong laxative compounds. Products made with aloe were at one time regulated by the U.S. Food and Drug Administration (FDA) as over-the-counter (OTC) laxatives.
Dandelion Root Extract– Dandelion (Taraxacum officinale) is a native plant to the United States and Europe, where the leaves and roots have been used as food and herbal medicine. The German Commission E and European Scientific Cooperative for Phytotherapy have approved the use of dandelion root to support hepatic and biliary function. Studies conducted in animals, have shown that dandelion root increases bile secretion as well as glutathione peroxidase, glutathione reductase and SOD (superoxide dismutase).
Senna Leaf extract– the leaves and the fruit of the plant are used to make medicine. Senna is an FDA-approved nonprescription laxative. It is used to treat constipation and also to clear the bowel before diagnostic tests such as colonoscopy. Senna is also used for irritable bowel syndrome (IBS), hemorrhoids, and weight loss.
Casanthranol USP (Cascara Sagrada bark extract)- Casanthranol is a stimulant type of laxative. The ingredient irritates the lining of the bowel to secrete fluid and so produce softer or more liquid bowel movements. Docusate or casanthranol is basically a detergent that is not absorbed by the body. It encourages the mixture of water and dietary fat within the stool, making the stool softer. It does not hold water like some bulking agents nor does it stimulate the bowel like true laxatives.