This specialized blend of 21 nutrients / ingredients in DrJsNatural Essential Liver Health has been shown to stimulate Phase I and II biotransformation and support the body’s natural liver cleansing function during detoxification. Each capsule includes 300mg Silymarin (milk thistle seed extract), Artichoke leaf extract, Turmeric root extract, Vitamin C, Beet Leaf, Black Radish Fruit, Bladderwrack leaves powder, Raspberry leaves powder, Pancreatin powder, Cleavers leaf powder, L-Glutathione, N-acetyl-L-cysteine, L-Methionine, Barberry root extract, Dandelion root extract, Schizandra fruit, Pueraria, Bupleurum Chinese Root, Cleavers leaf powder, and Grape Seed Extract . These botanicals and plant extracts contain phytonutrients, antioxidants and other compounds shown to increase cellular defenses, up-regulate detoxification, and protect DNA of the liver.
Silymarin (Milk Thistle Seed Extract) or (Silybum marianum) is an annual plant indigenous to Europe and the United States and has been used for centuries as an herbal medicine to support liver health. The extract of milk thistle has silymarin, the biologically active component found in the seeds and leaves of this plant. Silymarin provides liver protective effects via several mechanisms of action, including inhibiting lipid peroxidation; supporting liver detoxification through enhancement of the liver’s glucuronidation pathways; and protection against glutathione depletion. Silymarin has been shown to increase hepatocyte protein synthesis resulting in hepatic tissue function. Artichoke is one of the oldest cultivated plants. The ancient Greeks and Romans considered artichoke to be a valuable digestive aid. In traditional European medicine, the leaves of the artichoke were used as a diuretic to stimulate the kidneys and as a choleretic to stimulate the flow of bile from the liver and gallbladder. Artichoke leaf extracts have been shown to provide antioxidant and liver support, including the maintenance of healthy cholesterol levels and the prevention of lipid oxidation.
Beet Leaf (Beta vulgaris) has been used traditionally to help support liver function. Research has shown that beets are an excellent source of the nutrient betaine. Betaine acts as a methyl donor and supports the methylation detoxification pathway. Betaine assists in the conversion of homocysteine to methionine as well as increasing s-adenosylmethione (SAMe) levels. This prevents fat infiltration in the liver and protects against the free radical stress generated by toxic chemicals.
Curcumin, the active compound in Turmeric, an orange-colored spice used for thousands of years in cooking and medicine, has been shown to support the body’s antioxidant and detoxification pathways. Curcumin elevates cellular levels of glutathione, one of the body’s major antioxidants that protects cells against free radical damage. Curcumin has been shown to increase glutathione S-transferase (a phase II detoxification enzyme), as well as the enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase which results in a significant increase in a variety of antioxidant defenses. In a study examining the effects of curcumin on cells loaded with arsenic, curcumin effectively counteracted the effects of arsenic by increasing the activity of the primary detoxification enzymes SOD, catalase and glutathione peroxidase.
Dandelion Root Extract (Taraxacum officinale) is a native plant to the United States and Europe, where the leaves and roots have been used as food and herbal medicine. The German Commission E and European Scientific Cooperative for Phytotherapy have approved the use of dandelion root to support hepatic and biliary function. Studies conducted in animals, have shown that dandelion root increases bile secretion as well as glutathione peroxidase, glutathione reductase and SOD (Superoxide Dismutase) enzymes in the liver.
Methionine and Choline– Several studies have shown that the nutrients methionine and choline play a significant role in supporting normal liver cell function. Methionine and choline act as lipotropic agents which aid in fat metabolism as well as mobilization of fat out of the liver. Studies using mice fed a diet deficient in methionine and choline were found to have increased fatty acid uptake and decreased very-low-density lipoprotein (VLDL) secretion. These are just a few keys ingredients that will support and detox your liver in order to work at optimum level.
The human body is exposed to a wide variety of toxins on a daily basis, including chemicals found in foods, environmental toxins and pharmaceuticals drugs. The liver is the body’s main detoxification organ, and provides enzyme systems that safely process and remove xenobiotics and unhealthy hormone metabolites out of the body. These detoxification systems are very complex and require a variety of nutrients for optimal function. There are two main pathways of detoxification in the liver, known as Phase I and Phase II. Phase I, composed mainly of cytochrome P450 enzymes, involves non-reactive compounds undergo specific reactions which use oxygen to form a reactive site on the compound. Most pharmaceuticals are metabolized through Phase I biotransformation. This prepares the metabolite for the next step of detoxification, known as Phase II. Phase II is a crucial step- if molecules from Phase I are not fully metabolized by Phase II conjugation, they may cause free radical damage to proteins, RNA and DNA within the cell. Phase II reactions result in the biotransformation of fat-soluble compounds into water-soluble compounds that can then be excreted in the urine, bile or stool.
DrJsNatural Essential Liver Health’s botanicals and plant extracts contain phytonutrients, antioxidants and other compounds that naturally protect the liver from environmental challenges including exposure to radiation, toxins and infectious agents. In humans, these biologically active compounds have been shown to increase cellular defenses, up-regulate liver detoxification pathways and protect DNA.